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Furthermore, we show that downregulation of lipid metabolism via CPT1 alleviates pathological motor and non-motor behavior, oxidative stress, and disrupted glucose homeostasis in Park2 knockout mice

Clinical Reviews in Allergy and Immunology

The study found that FOS/GOS supplementation inhibited the dysregulated expression of intestinal epithelial gap junction proteinsincluding Claudin-1, Claudin-15, Zonula occludens-1 (ZO-1), and Junctional adhesion molecule-Athereby mitigating barrier damage and reversing HFD-induced hyperpermeability

Such imbalances have been associated with increased susceptibility to infections as well as a higher risk of autoimmune diseases and certain cancers [44]